
SaltStable LO™ is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It’s uniquely designed for long shelf, temperature and physical stability; it will not separate in the presence of high levels of ionic substances or when refrigerated. It uses emulsifiers and hydrocolloids that provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmetically elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility.
SaltStable LO™ Benefits:
- Efficacious active drug absorption
- Validated in vitro transdermal penetration & API compatibility
- Temperature stable & two year shelf stable
- Hydrophilic compatibility – high levels of ionic powders can be directly incorporated
- Lipophilic compatibility – moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol
- Cosmetically elegant – not tacky or sticky
- Natural ingredients – resulting in less irritation
When do you need SaltStable LO™?
- When you want a more efficacious active drug absorption than with PLO.
- When you want to incorporate high levels of ionic substances.
- When you want a creamier, more cosmetically elegant and less sticky base than with a PLO.
- When you want a penetrating cream that can be refrigerated.
- When you want 90 day beyond-use-dating.
SALTSTABLE LO PROPERTIES:
pH | 7.0 |
Specific Gravity | 1.00 g/mL |
Viscosity | 300,000 cps |
Physical Forma | Heavy Cream |
Color | Light Beige |
Transdermal Penetration | ++++ |
API Compatibility | Hydrophilic 35% & Lipophilic 10% - Total API Load 35% |
Typical Applications | Pain Management, Sports Medicine, Veterinary Medicine |
Additional Resources
- SaltStable LO Transdermal Study
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- Benzocaine Report in SSLO
- Clomipramine Hydrochloride Report in PENCream & SSLO
- Cyclobenzaprine Report in SSLO
- Diphenhydramine Hydrochloride Report in SSLO
- Fluoxetine Hydrochloride Report in SSLO & PENCream
- Gabapentin Report in LipoBase Regular, PENcream, SSLO, LipoBase Heavy, PLO20 Regular
- Ketoprofen Report in PLO20 Regular, SSLO, PENcream
- Lidocaine Report in SSLO, PENCream, Multibase
- Methimazole Report in PLO20 Flowable, SSLO, LipoBase Regular, PENcream
- Metronidazole Report in SSLO, PENCream, Multibase, HRT Heavy
- Promethazine Report in PLO20 Regular, SSLO, LipoBase Heavy, PENCream
- Tetracaine Hydrochloride Report in PENCream and SSLO
- Safety Data Sheet