SaltStable LO™ is a ready-­to-­use transdermal cream base providing an elegant alternative to traditional PLOs. It’s uniquely designed for long shelf, temperature and physical stability; it will not separate in the presence of high levels of ionic substances or when refrigerated. It uses emulsifiers and hydrocolloids that provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmetically elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility.

SaltStable LO™ Benefits:

  • Efficacious active drug absorption
  • Validated in vitro transdermal penetration & API compatibility
  • Temperature stable & two­ year shelf stable
  • Hydrophilic compatibility – high levels of ionic powders can be directly incorporated
  • Lipophilic compatibility – moderate levels of oil­-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol
  • Cosmetically elegant – not tacky or sticky
  • Natural ingredients – resulting in less irritation

When do you need SaltStable LO™?

  • When you want a more efficacious active drug absorption than with PLO.
  • When you want to incorporate high levels of ionic substances.
  • When you want a creamier, more cosmetically elegant and less sticky base than with a PLO.
  • When you want a penetrating cream that can be refrigerated.
  • When you want 90­ day beyond­-use-­dating.


pH 7.0
Specific Gravity 1.00 g/mL
Viscosity 300,000 cps
Physical Forma Heavy Cream
Color Light Beige
Transdermal Penetration ++++
API Compatibility Hydrophilic 35% & Lipophilic 10% -­ Total API Load ­ 35%
Typical Applications Pain Management, Sports Medicine, Veterinary Medicine

Additional Resources