SaltStable LS Advanced™ is an extension and enhancement of SaltStable LO™. SaltStable LS Advanced™ is a scientifically advanced, extremely durable, robust and versatile transdermal cream base formulated with a silogel that provides a smooth, silky dry feel. Designed for all actives and is non­specific to salt, it exhibits superior API carrying capacity (high loads) of multiple actives in one formulation. SaltStable LS Advanced™ demonstrates excellent stability without the need to add emulsifiers.

SaltStable LS Advanced™ Benefits:

  • Increased stability with a high percent of APIs & multiple actives
  • Validated in vitro transdermal vehicle up to 8 APIs in one formulation
  • Less sticky & less tacky because of silogel (silicone­-based organogel)
  • Off­-white, cosmetically elegant cream
  • API compatibility – compatible with all actives, non­specific to salt
  • Time saving – ready­-to-­use base, no need for wetting or adding
    thickening agents
  • Ideal for formulations with multiple actives & high API loads


pH 7.1-­7.5
pH Compatibility Broad Range
Specific Gravity 0.90 g/mL
Viscosity 1,200,000 cps
Physical Format Heavy Cream
Color Off White
Transdermal Penetration ++++
API Compatibility Hydrophilic 30% & Lipophilic 40% -­ Total API Load ­ 40%

Published Science

Trimble, J. “Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives.” International Journal of Pharmaceutical Compounding. 20.3 (May/June 2016) 250-256.

Additional Resources