PLO20™ is a ready-to-use, absorption-enhanced transdermal vehicle that is an elegant alternative to PLO transdermal systems. It contains penetration enhancers to facilitate more efficacious active drug absorption, emollients for a better rub-in, preservatives for increased mold resistance, along with emulsifiers allowing for better cold-temperature stability. PLO20™ and PLO20™ Flowable may be blended for viscosity optimization without wetting agents or milling to thin the formula, thus allowing for versatile compounding.