SaltStable LO™ is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It's uniquely designed for long shelf, temperature and physical stability; it will not separate in the presence of high levels of ionic substances or when refrigerated. It uses emulsifiers and hydrocolloids that provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmetically elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility.